"1And He began to speak to them in parables: “A man PLANTED A VINEYARD AND PUT A WALL AROUND IT, AND DUG A VAT UNDER THE WINE PRESS AND BUILT A TOWER, and rented it out to vine-growers and went on a journey. 2“At the harvest time he sent a slave to the vine-growers, in order to receive some of the produce of the vineyard from the vine-growers. 3“They took him, and beat him and sent him away empty-handed. 4“Again he sent them another slave, and they wounded him in the head, and treated him shamefully. 5“And he sent another, and that one they killed; and so with many others, beating some and killing others. 6“He had one more to send, a beloved son; he sent him last of all to them, saying, ‘They will respect my son.’ 7“But those vine-growers said to one another, ‘This is the heir; come, let us kill him, and the inheritance will be ours!’ 8“They took him, and killed him and threw him out of the vineyard. 9“What will the owner of the vineyard do? He will come and destroy the vine-growers, and will give the vineyard to others." Mark 12.
The religious leaders in Jerusalem were pictured in the parable as those who rejected every kindness of God. In every way they resisted His will. And Jesus indicates that they will commit worst sin by killing the Son.
Looking more broadly, God is always in charge of the world and has interest that men further His divine work. Each man in this world is either advancing or impeding the righteous work of God. Men either honor the Son or else they reject Him. On judgment day, every man will be call to account for what he did in God's vinyard, the world, and how he responded to Jesus Christ, the Son.